Journal article
Analgesic effect of central relaxin receptor activation on persistent inflammatory pain in mice: behavioral and neurochemical data
C Abboud, L Brochoire, A Drouet, MA Hossain, W Hleihel, AL Gundlach, M Landry
Pain Reports | LIPPINCOTT WILLIAMS & WILKINS | Published : 2022
Abstract
Introduction: The relaxin peptide signaling system is involved in diverse physiological processes, but its possible roles in the brain, including nociception, are largely unexplored. Objective: In light of abundant expression of relaxin receptor (RXFP1) mRNA/protein in brain regions involved in pain processing, we investigated the effects of central RXFP1 activation on nociceptive behavior in a mouse model of inflammatory pain and examined the neurochemical phenotype and connectivity of relaxin and RXFP1 mRNA-positive neurons. Methods: Mice were injected with Complete Freund Adjuvant (CFA) into a hind paw. After 4 days, the RXFP1 agonist peptides, H2-relaxin or B7-33, 6 the RXFP1 antagonist,..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This research was supported by grants from the French National Research Agency (A.N.R.)-RELAX Grant, Agreement 193992 (A.L.G. and M.L.), the National Health and Medical Research Council (NHMRC) of Australia (2001278 [M.A.H.] and 1067522 [A.L.G.]). C. Abboud was the recipient of a postgraduate scholarship from the "Centre National de la Recherche Scientifique Libanais" (Lebanon). Imaging was performed at the Bordeaux Imaging Center, a member of the France BioImaging national infrastructure (ANR-10-INBS-04).